Abstract
The heart is an organ with a continuous activity whose heart rate and strength contractions are modulated by several physiological subsystems. These subsystems can be seen as weakly coupled oscillators. The electrical and mechanical oscillators are considered in this manuscript. 1:1 synchronization mode is a typical response of the healthy heart. However, although the heart rhythm as a system of weakly coupled oscillators was studied recently, little attention has been paid to the synchronization modes of the electrical stimulation-contractile response coupling in isolated mouse heart. This study aimed to describe with a minimalistic mathematical model the synchronization modes on the electrical stimulation-contractile response coupling in the whole heart. In this paper, we propose a minimal linear coupled oscillator model to study the synchronization modes. It contains four variables, and it is validated with experimental results. The local stability is studied. We predict through in-silico experiments the presence of several synchronization modes, and these could be associated with arrhythmias.
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