Abstract
It has been fifty years since the discovery that Ca2+ triggers the rapid exocytosis of neurotransmitters from neurons. One of the proteins that has a crucial role in this secretion event is synaptotagmin I, an abundant constituent of synaptic vesicles that binds Ca2+ ions through two C2 domains. These properties prompted the idea that synaptotagmin I might function as a Ca2+-sensor that triggers neurotransmitter release. So does synaptotagmin trigger exocytosis in a Ca2+-dependent manner, and, if so, how does it operate?
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