Synaptic transmission in the inferior mesenteric ganglion of hypertensive and normotensive rats

Abstract

The inferior mesenteric ganglion (IMG) is a prevertebral sympathetic ganglion that innervates the lower abdominal and pelvic viscera. While extensive studies have been performed on the IMG of several species, there is very little information available concerning the rat IMG. Because of the importance of the mesenteric circulation in the regulation of systemic blood pressure and in the genesis of salt‐sensitive hypertension, we compared the properties and response profiles to pre‐ganglionic input of IMG neurons in normotensive (NT) and hypertensive (HT) animals using intracellular recording in vitro. All rats were uninephrectomized 4 weeks prior to experiments. HT rats received 200mg/kg of deoxycorticosterone s.q. and 1%NaCl/0.2%KCl in drinking water. NT animals (mean arterial pressure < 130mmHg) received tap water. Resting membrane potential, rheobasic current, action potential amplitude, input resistance, and membrane time constant show no significant differences between NT and HT animals. In contrast to the findings in the IMG of other species, nearly all neurons (94% in HT, 91% in NT rats) showed a phasic response to direct current injection. This is the first study of the IMG of the hypertensive rat. While there is a predominance of phasic neurons in this ganglion, changes in sympathetic outflow that occur with hypertension are not due to alterations in the basic properties of the ganglionic neurons. Supported by NIH grant HL70687