Abstract
The expression and kinase activity of cyclin dependent kinase 5 (cdk5) parallels the extent of neuronal differentiation. Cdk5 activity has been shown to be required for neurite outgrowth, cortical lamination and the overall development of the nervous system. p35 was identified as the first regulatory activator of cdk5 whose presence is required for cdk5 activation. p39 is a homolog of p35, and the only one identified in mammals thus far. We show here that p39 expression is mainly postnatal. In addition, we provide evidence for the presence of p39 at synaptic junctions through co-fractionation experiment, electron microscopy and immunostaining. The temporal and spatial expression of p39 indicate a possible role of the p39/cdk5 kinase at the synapse.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
