Synapsin-i Expression in the Rattus norvegicus Pup's Brain from Rat's Maternal Death Model

Abstract

Maternal mortality could be a neonatal stressor that activated the HPA axis to secret glucocorticoids as a marker of stress. Brain development took place rapidly in the first 1, 000 days of life. Synapsin-I was involved in the early development of the brain's nervous system. The purpose of this study was to analyze the impact of separation of Rat's pup and mothers as a maternal death model on the expression of synapsin-I in the cerebrum and cerebellum of 3 days old Rattus norvegicus pups. The control group (K1) consisted of newborn Rattus norvegicus which remained with the mother, while the treatment group (K2) consisted of newborn Rattus norvegicus which was separated from the mother. After 3 days of observation, Rattus norvegicus pups from each parent were taken with the heaviest, medium, and lowest weights to be sacrificed and examined by imonohistochemical of synapsin-I expression. Analysis of the Mann Whitney test for synapsin-I expression in Rattus norvegicus cerebrum showed a significant difference between the control group and the treatment group with a value of p=0, 000 (p<0.05). Independent T test analysis of synapsin-I expression in Rattus norvegicus cerebellum also showed a significant difference between the control group and the treatment group with a value of p=0, 000 (p<0.05). Synapsin-I expressions in the cerebrum and cerebellum of Rattus norvegicus pups that separated from the mothers were lower than those that not separated from the mothers.