Abstract

This analysis was undertaken to examine the relationship between different symptoms of major depressive disorder (MDD) and psychosocial functioning from the perspectives of patients and healthcare providers (HCPs) across the different phases of the disease (acute, post-acute, and remission). Data regarding symptoms of MDD and psychosocial functioning, assessed by an adapted version of the Functioning Assessment Short Test (FAST) scale, were elicited via an online survey from 2,008 patients diagnosed with MDD (based on their personal experience of the disease) and 3,138 patients observed by 1,046 HCPs (based on individual patient records). Correlations between patient-reported and HCP-reported MDD symptoms and impairment of psychosocial functioning were assessed by multivariate regression analysis. The population comprised 1,946 patient respondents and 3,042 HCP-reported patients. Patients reported experiencing a wider range of symptoms and greater impairment of functioning than reported by HCPs across all phases of the disease. At the domain level, only cognitive symptoms were found to be significantly associated with functioning during the acute phase from the perspective of patients, while from the HCPs’ perspective both mood and cognitive symptoms significantly impacted functioning in this phase. Significant associations were seen between mood, physical, and cognitive symptom domains and functioning in both cohorts during the post-acute and remission phases. Differences in associations between individual MDD symptoms and functioning were also observed between the two cohorts across all disease phases; in particular, HCPs found that more physical symptoms impacted functioning during remission than did patients. In summary, the results suggest that perceptions of MDD symptoms and the associations between these symptoms and functioning differ significantly between patients and HCPs across all phases of the disease. These findings further highlight the need for improved communication between patients and HCPs in order to set appropriate treatment goals and promote symptomatic and functional recovery in MDD.

Highlights

  • Major depressive disorder (MDD) is a complex and multidimensional condition [1], which is associated with significant impairment of psychosocial functioning and healthrelated quality of life [2,3,4]

  • We found that patients more frequently reported mood, physical, and cognitive symptoms than healthcare providers (HCPs) reported with regard to their patients, during the post-acute and remission phases of MDD

  • In terms of disease phase, 406, 767, and 773 responses were included for the patient-reported cohort and 1,005, 1,017 and 1,020 for the HCP-reported cohort for the acute, post-acute, and remission phases, respectively

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Summary

Introduction

Major depressive disorder (MDD) is a complex and multidimensional condition [1], which is associated with significant impairment of psychosocial functioning and healthrelated quality of life [2,3,4]. Clinical presentation is highly heterogeneous, and large variations in symptom profiles exist between individual patients [6, 7]. Both symptomatic and functional recovery are required if patients with MDD are to return to productive and fulfilling daily lives [8,9,10]; achieving these treatment goals remains challenging in clinical practice. 50% of patients with MDD do not respond adequately to initial antidepressant treatment [11], with patients who achieve only partial response experiencing significant impairments in overall functioning compared with those who achieve remission [12]. Residual symptoms during periods of remission have been shown to be strong predictors of subsequent relapse in patients with MDD [13,14,15,16,17,18]

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