Symptoms of Dry Eye Disease in Hospitalized Patients with Coronavirus Disease 2019 (COVID-19).

Yan Wang,Pengxiang Zheng,Sen Yang,Yue Zhang,Yihui Chen,Xin Zhang,Yaping Jiang,Xixi Wang,Giovanni William Oliverio

doi:10.1155/2021/2678706

Yan Wang, Pengxiang Zheng + Show 7 more

Open Access

https://doi.org/10.1155/2021/2678706

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Abstract

Background We aimed to investigate the symptoms of the dry eye disease (DED) of hospitalized patients with coronavirus disease 2019 (COVID-19). Methods This cross-sectional, observational study analysis included 91 hospitalized patients with confirmed COVID-19 in Wuhan, China. The Ocular Surface Disease Index (OSDI) and the five-item Dry Eye Questionnaire (DEQ-5) were used to assess the severity of DED symptoms in the patients, and the analysis of variance was used to determine the factors associated with DED. Results A total of 42 patients consented to complete the investigation (response rate 46.15%). There were 26 (61.90%) patients who were diagnosed with DED symptoms by OSDI, and there were 28 (66.67%) patients with DED symptoms who were diagnosed by DEQ-5 score. For the biochemical tests, the patients with DED symptoms had lower aspartate aminotransferase (AST) levels compared to those with no DED symptoms (20.86 vs. 42.14, p=0.04). Further analysis showed that a previous history of cardiac or stroke disease (p=0.02) and typical symptoms of muscle soreness (p=0.03) were significantly different among the four DED symptoms groups on the basis of OSDI scores. The contributing factors of OSDI were mainly focused on visual function and environmental triggers. Conclusion The incidence of DED symptoms is higher in hospitalized patients with COVID-19. The serum AST levels, history of cardiac or stroke disease, and the typical symptoms of muscle soreness may be the main impact factors on DED symptoms. We also need to pay more attention to the visual function and environmental triggers of hospitalized patients with COVID-19.

Highlights

At the end of 2019, coronavirus disease 2019 (COVID-19) broke out in Wuhan, China, and it has become a global pandemic caused by the highly transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1,2,3,4]
It is well known that, for most coronavirus infections, clinically significant conjunctivitis is rare, but there are some eye symptoms in hospitalized COVID-19 patients, such as eye dryness, blurred vision, eye soreness, and eye itch. us, we would like to determine the subclinical involvement of the anterior ocular surface
We investigated the subjective ocular symptoms of dry eye disease in a group of patients hospitalized with the confirmed diagnoses of COVID-19 in the epicenter of Wuhan

Summary

Introduction

At the end of 2019, coronavirus disease 2019 (COVID-19) broke out in Wuhan, China, and it has become a global pandemic caused by the highly transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [1,2,3,4]. E Ocular Surface Disease Index (OSDI) and the five-item Dry Eye Questionnaire (DEQ-5) were used to assess the severity of DED symptoms in the patients, and the analysis of variance was used to determine the factors associated with DED. Further analysis showed that a previous history of cardiac or stroke disease (p 0.02) and typical symptoms of muscle soreness (p 0.03) were significantly different among the four DED symptoms groups on the basis of OSDI scores. We need to pay more attention to the visual function and environmental triggers of hospitalized patients with COVID-19

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Results