Abstract
To raise awareness about preventive measures in COVID-19 pandemic, even though fully vaccinated. Although recent trials showed high efficacy of vaccines in preventing symptomatic infections, there are some individuals experiencing symptomatic SARS-CoV-2 infection. In this case report, a fully vaccinated young dental practitioner experienced symptomatic SARS-CoV-2 infection 55 days postvaccination with BNT162b2 Pfizer vaccine with evident ageusia. Diagnostic swabs were performed and used for viral genome sequencing. The patient fully recovered 15 days after diagnosis. Loss of smell and taste, together with nasal congestion were the main reported symptoms. The use of personal protective equipment prevented spread of infection in patients and co-workers. With the increase of people being fully vaccinated, it is still necessary to follow infection preventive protocols by correctly applying personal protective equipment. Although high efficacy has been proved, some individuals may still be vulnerable to symptomatic infection and new guidelines and markers should be adopted and investigated to find out patients for whom vaccination may not determine full immunization.
Highlights
After the SARS-CoV-2 pandemic, the hope of the whole world is placed in the effectiveness of vaccines that should ensure immunity to the entire population
The FDA authorized early the new mRNA-based vaccines. Their short-term efficacy has been comparable with that of other common vaccines in phase 3 trials and a reduced symptomatic SARS-CoV-2 infection by over 90% was observed in healthy participants, after vaccination [1,2]. mRNA vaccines were developed to mitigate severe COVID-19 disease [3], showing successful results
In order to deeply understand these mechanisms, it could be useful, whenever it is possible, to perform viral DNA sequencing and testing for immune-related markers in patients with breakthrough infections. This case outlines some useful considerations; firstly, the classic variant of SARSCoV-2 infected a healthy subject, 55 days postvaccination, pointing out that breakthrough infection is possible after vaccination in healthy subjects with common variants; in addition, it is necessary to continue observing all the prescriptions recently indicated in the literature in order to avoid new contagion for all healthy workers after vaccination, since, as seen, the vaccination does not ensure complete immunity in 100% of cases
Summary
After the SARS-CoV-2 pandemic, the hope of the whole world is placed in the effectiveness of vaccines that should ensure immunity to the entire population. For this reason, the FDA authorized early the new mRNA-based vaccines. The FDA authorized early the new mRNA-based vaccines Their short-term efficacy has been comparable with that of other common vaccines in phase 3 trials and a reduced symptomatic SARS-CoV-2 infection by over 90% was observed in healthy participants, after vaccination [1,2]. To our knowledge, the first case of an Italian fully vaccinated dental practitioner in whom symptomatic infection emerged This unique case was described by the patient himself. Public Health 2022, 19, 886 published reports in fully vaccinated individuals and by publishing several case reports would be useful for understanding COVID-19 disease in vaccinated people, improving prognostication, patients’ selection and general public health policies
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