Abstract
"Over-the-wire" thrombolysis was successfully accomplished in eight patients with symptomatic lower-extremity ischemia. The authors used a 5-F catheter with multiple side holes designed to pulse-spray urokinase directly over the guidance of a 0.035-inch guide wire. The mean occlusion length was 11.5 cm (range, 5-27 cm). Complete thrombolysis was achieved after delivery of a mean of 480,000 IU of urokinase in a mean infusion time of 48 minutes. One embolic complication was successfully treated with the catheter-wire system. No bleeding complications occurred. Over-the-wire thrombolysis is an alternative method of administering urokinase for the treatment of arterial occlusions.
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