Abstract
Despite the fact that pharmacologists and some clinicians are aware that physical, chemical, and pharmaceutic properties of a drug may influence its actions and effects, little consideration has been given to quantitating the effects of these properties. It is the aim of this article to discuss and illustrate the fact that the rate of gastrointestinal absorption of a drug is often a function of the time needed for the drug to dissolve in the fluid at the site of absorption. Clinical trials of several forms of the same drug may merely confirm a result which should have been predicted on the basis of its properties, such as specific surface area, type of salt, and the form in which it is administered.
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