Abstract
AbstractRecent investigations have shown that nonsusceptible strains of mice can be made susceptible to audiogenic seizures by exposing them to intense sound during a “sensitive period.” The parameters of seizures behavior that accompany this priming procedure have been studied extensively and more recently the physiological processes that are associated with this phenomenon have received attention. The results indicate that priming causes a severe loss in cochlear microphonic sensitivity and extensive damage to basal turn hair cells. The patterns of evoked response activity in peripheral auditory nuclei show a loss in threshold sensitivity at low stimulus levels and over recruitment of response amplitude at high stimulus levels. Although there is a severe loss of cochlear function in these animals, intense stimuli paradoxically evoke exceptionally large re‐responses and precipitate seizure behavior. Several hypotheses concerning this paradox are offered, and the potential significance of the priming phenomenon is considered.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
