Abstract
The influence of amphetamine, apomorphine and methylphenidate on basal gastric secretion was investigated using fistula‐ and pylorus‐ligated rats. The antisecretory effect of amphetamine was reversed by pretreating the animals with α‐methyl‐p‐tyrosine (α‐MT). Moreover the decreased output following methylphenidate in shay‐rats was reduced by α‐MT pretreatment. On the other hand α‐MT was not able to antagonize the antisecretory effect of methylphenidate in fistula rats. Apomorphine exhibited antisecretory properties in fistula rats and gastric stimulating effects in shay‐rats, the latter effect being reversed by α‐MT pretreatment. The results obtained indicate that the antisecretory effects of amphetamine and methylphenidate may be due to their amine releasing properties.
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