Abstract
Dysfunctions of the sympathetic nerve system may contribute to the development of obesity. The melanocortin system is critically involved in maintenance of energy balance. Activation of the melanocortin-4 receptor (MC4-R) leads to a decrease of appetite and an elevation of sympathetic nerve activity (SNA). Recently it has been shown that known sympathoactivation to leptin is mediated by the melanocortin system and a functional MC4R is a prerequisite for the development of hypertension associated with obesity in animal model.
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