Abstract
The sympathetic innervation of the normal human thyroid was investigated by a combination of fluorescence histochemistry and electron microscopic autoradiography. Sympathetic, adrenergic nerve fibers were numerous in the human thyroid, and they were mainly found in two locations: in relation to vessels, and in interfollicular spaces. The terminals of the vascular nerves were located very close to smooth muscle cells in the vessel wall, and the interfollicular nerve terminals had a similarly close relation to follicle cells; only the respective basement membranes intervened. It is concluded that, in man, there is a morphological basis for an influence of the sympathetic nervous system not only on thyroid vessels but also directly on thyroid follicle cells.
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