Abstract
In this work, a method has been developed for the formal, multi-component reaction of cyclopropyl dicarboxylates, aldehydes, and amines under ultrasonic irradiation. The symmetrical dibromide salt (A) was prepared from the reaction of 1,2-bis(2-bromoethoxy)ethane with 2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidine in toluene under reflux condition. CeCl3 and compound (A) were used as catalyst and promoter and showed a good potential for application in the synthesis of a range of structurally diverse pyrrolidine rings in short reaction times (3–5 h) and excellent yields (89–97 %).
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