Abstract
A 42-year-old Caucasian female patient presented with symmetric, asymptomatic, periorbital angioedema (Fig. 1) that appeared 24 hours after the second dose of the Moderna mRNA COVID-19 vaccine. She was injected with the hyaluronic acid dermal filler Juvéderm Volite in the glabella and periorbital area three months earlier and underwent a botulinum toxin session in the forehead, glabella, and crow’s feet with Vistabel six months earlier. No present or previous history of allergy or concomitant diseases was reported. Cetirizine dihydrochloride 3 × 10 mg and cold compresses resulted in the complete resolution of the symptoms within three days. Reactions to the Moderna vaccine possibly related to the dermal filler placement are rare and have an unknown pathogenesis. Three out of 15,184 patients developed facial or lip swelling after mRNA vaccine [1]. These reactions may be immunologically triggered by viral or bacterial illness and vaccinations, including allergies to vaccine ingredients such as polyethylene glycol.
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