Symbol Recurrence Plots based resting-state eyes-closed EEG deterministic analysis on amnestic mild cognitive impairment in type 2 diabetes mellitus

Abstract

This paper proposes a new Recurrence Plots method—Symbol Recurrence Plots (SRP), and uses Determinism of SRP (SRP_DET) to quantify the determinism of EEG. The performances, including the effects of weighting coefficients and signal to noise ratios of the SRP are evaluated by using double kinetics Neural Mass Model. The simulation analysis illustrates that SRP had better performances than Permutation patterns Recurrence Plots (PRP). Then, the dynamic characteristics of resting-state eyes-closed EEG of amnestic MCI group and age-matched normal control group in T2DM are analyzed. The results show that SRP_DET of aMCI group has significantly higher values at 12 electrodes, which indicates an increase of EEG regularity in the temporal and occipital regions, but PRP_DET values only at one electrode C4. Correlation analysis shows that SRP_DET is strictly negative correlated to MoCA and memory functions at electrodes P4, whereas PRP_DET is not found to be correlated. Therefore, SRP_DET is suggested to be an effective index to understand the deterministic characteristics of cognitive impairment in T2DM.