Abstract
The influence of microbiological species has gained increased visibility and traction in the medical domain with major revelations about the role of bacteria on symbiosis and dysbiosis. A large reason for these revelations can be attributed to advances in deep-sequencing technologies. However, the research on the role of fungi has lagged. With the continued utilization of sequencing technologies in conjunction with traditional culture assays, we have the opportunity to shed light on the complex interplay between the bacteriome and the mycobiome as they relate to human health. In this review, we aim to offer a comprehensive overview of the human mycobiome in healthy and diseased states in a systematic way. The authors hope that the reader will utilize this review as a scaffolding to formulate their understanding of the mycobiome and pursue further research.
Highlights
The role of commensal and pathologic bacteria in influencing human health has been studied for over a century with numerous direct correlations to disease states as well as symbiotic conditions (Ubeda et al, 2017; Ranjan and Dongari-Bagtzoglou, 2018; Libertucci and Young, 2019)
With increased understanding of the impact that microbes have in the human physiology and pathology, and advancing technology, there has been an emphasis on exploring the interplay between bacterial and fungal communities as it relates to human health (Ghannoum, 2016)
Patients with cystic fibrosis (CF) who suffer from Psuedomonas aeruginosa infection are frequently found to have persistent infections from Aspergillus fumigatus or C. albicans compared to patients without these fungi (Amin et al, 2010; Chotirmall et al, 2010)
Summary
Specialty section: This article was submitted to Microbial Symbioses, a section of the journal Frontiers in Microbiology. The influence of microbiological species has gained increased visibility and traction in the medical domain with major revelations about the role of bacteria on symbiosis and dysbiosis. A large reason for these revelations can be attributed to advances in deep-sequencing technologies. The research on the role of fungi has lagged. With the continued utilization of sequencing technologies in conjunction with traditional culture assays, we have the opportunity to shed light on the complex interplay between the bacteriome and the mycobiome as they relate to human health. We aim to offer a comprehensive overview of the human mycobiome in healthy and diseased states in a systematic way. The authors hope that the reader will utilize this review as a scaffolding to formulate their understanding of the mycobiome and pursue further research
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