Abstract
Abstract Dendritic cells (DCs) activated via TLR ligation experience metabolic reprogramming, in which the cells are heavily dependent on glucose and glycolysis for the synthesis of molecular building blocks essential for maturation, cytokine production, and the ability to stimulate T cells. Although the TLR-driven metabolic reprogramming events are well documented, fungal-mediated metabolic regulation via C-type Lectin Receptors such as Dectin-1 is not clearly understood. Here, we show that activation of DCs with fungal-associated ligands induces acute glycolytic reprogramming that supports the production of IL-1b via inflammasome activation. This acute glycolytic induction to fungal-associated ligands is depending on Syk signaling in a TLR-independent manner, suggesting now that different classes of innate immune receptors functionally induce conserved metabolic responses to support immune cell activation. These studies provide new insight into the complexities of metabolic regulation of DCs immune effector function regarding cellular activation associated with protection against fungal microbes.
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