Abstract
It has been well recognized that investigator-initiated academic clinical trials is an important component in developing practice-changing cancer treatment, for instances, FOLFIRINOX in metastatic and resectable pancreatic cancer and FLOT in locally advanced gastric cancer. Because of the difference in prevalent cancer types, pharmacogenomics, tumor biology and/or associated genetic alterations, and new drug approval/reimbursement, clinical practice pattern and subsequent patient outcomes between Eastern and Western populations, the role for such academic clinical intervention trials, including real-world data (RWD) collection registration trials, to investigate the safety and efficacy of repurposing or new agents for new indications evaluation is even more relevant in Asia.
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