Abstract
Alcohol shows multiple actions on function of various cells including neurons. Although alcohol dependence is a complex condition with clear genetic factors, recent investigations have revealed the data for understanding the complexity and dinamicity of the effect of alcohol. Acute effects of alcohol are, at least in part, mediated via direct action on ligand gated ion channels, such as GABA(A) receptors and NMDA receptors, and phosphorylation of these channels. Chronic effects of alcohol are may due to modification of gene expression following protein alteration of these channels. In fact previous biochemical and electrophysiological experiments have demonstrated functional alteration of neurotransmitter receptors and ligand gated ion channels by ethanol at the concentrations observed in alcoholics. Furthermore, our recent study shows that alcohol induced up-regulation of intracellular calcium channels in animal brain with alcohol dependence. This presentation therefore shows the relationship between ethanol-induced rewarding effect and ligand gated ion channels, especially type I IP3 receptors and GABA(A) receptors, and Cl- transporter expression in animal brain with alcohol dependence.
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