Abstract
The standard treatment for locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) is surgery ± postoperative (chemo)radiation therapy [(C)RT] or definitive CRT. The standard concurrent chemotherapy regimen is tri-weekly cisplatin. In the postoperative setting, weekly cisplatin is an alternative option. For laryngeal preservation, induction docetaxel, cisplatin, and 5-FU followed by (C)RT is the treatment option. Recently, the efficacy of combined immunotherapy and CRT for curative intent has been reported.
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