SY11-2 Tumor organoid models for translational research and co-clinical applications

Abstract

In recent years, the appetite for using 3D culture methods is overshadowing the use of monolayer cultures. The ability to design organ-specific media conditions to support the growth of primary or stem cells in 3D culture conditions and use these conditions to induce organotypic growth has catapulted the field to a new dimension. These organotypic culture methods have become a mainstay in developmental biology, regenerative medicine, and cancer biology. I will discuss our efforts to develop and use 3D culture methods for growing patient-tumor-derived cancer cells as tumor organoids to personalize cancer treatments.