Abstract
Effector T cells play an important role for killing abnormal cells such as cancer cells. On the other hand, regulatory T (Treg) cells are essential in immunosuppression to control over-activation of immune responses and maintain immune tolerance. These immune cells are guided from the circulation into local tissues, such as the tumor microenvironment (TME), to exert their functions by the chemokine networks. We clarified the mechanisms by which EGFR-mutated non-small cell lung cancers make non-inflamed TME, while promoting Treg infiltration via CCL22 production.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
