Abstract
Effect of swimming training is considered on doxorubicin-induced toxicity in the liver, heart, and kidney of rats. Histopathological degeneration could partially be prevented in swimming-trained rats pretreated with garlic extract. Exercise combined with garlic extract reduced the malondialdehyde value and improved the activities of antioxidant enzymes. Doxorubicin treatment enhanced the mean values of blood ALT, AST, and ALP enzymes, as well as hepatic, cardiac, and renal TNF-α and HSP70 (p < .05). Swimming alone or supplemented with garlic extract can protect liver, heart, and kidney against doxorubicin toxicity by increasing antioxidants and reducing oxidative stress and inflammation.
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