Abstract
Because sex hormones affect basic cardiac properties, this study investigated the adaptibality of the heart in the context of a sex hormone deficiency caused by ovariectomy (OVX). Twenty four rats (10 months old) were assigned to the following groups: Sham-Sedentary (S-S), Sham-Exercised (S-E), OVX sedentary (O-S), and OVX-exercised (O-E). Exercised animals progressively increased their swimming times until they were swimming 75 min/day, 5 times per week. After 9 weeks, animals were sacrificed, hearts removed, and spectrophotometrically analyzed for maximal citrate synthase (CS), hexokinase(HK), and B-hydroxyacyl CoA dehydrogenase (HOAD) activity. Myosin isoenzymes were separated by PAGE electrophoresis and quantified. Two-way ANOVA reveled that training, but not OVX, increased the activity of these metabolic enzymes OVX treatment slightly, but significantly, altered the myosin isoenzyme profile. These results demonstrate that sex hormone levels in older rats 1) do not impact cardiac metabolic adaptations to swimming, and 2) have a nominal effect on the myosin isoenzyme profile, a marker of intrinsic contractility.Table
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