Abstract
Background: Pseudoexfoliation syndrome (PEX) is a systemic, age-related disorder characterized by the production and accumulation of pseudoexfoliation material. To date, detailed characteristics have not been published regarding the iridocorneal angle and cornea in patients with pseudoexfoliation syndrome determined through swept source optical coherence tomography (SS-OCT). Methods: A total of 150 eyes of patients with pseudoexfoliation syndrome (ages 69–86 years) and 166 eyes in a control group (ages 54–79 years) were analyzed. Results: The central corneal thickness in the PEX group was 549.56 μm and was slightly (insignificantly) higher than that of the control group (540.56 µm). The anterior chamber of the eye was visibly shallower in patients with PEX syndrome than in those of the control group (2.49 mm vs. 3.07 mm; p < 0.001). The Fourier analysis parameters of the cornea showed multiple differences between the PEX and control groups. With respect to iris area, the parameters showed statistically significant differences between the PEX and control groups in all four quadrants of the eye. No statistical significance was found in the PEX group for the iridocorneal angle parameters, or corneal and lens parameters depending on gender and age. Conclusions: PEX syndrome is characterized by a significant impact on the anterior eye segment, including higher anterior and posterior keratometric values, lower anterior chamber depth, higher iris thickness, and narrower angle parameters. The characteristic anterior eye segment features of PEX syndrome can be detected using SS-OCT, which could potentially assist clinicians in properly managing the disease.
Highlights
Optical coherence tomography (OCT), is a non-contact precise tissue imaging technique that was developed in 1991 [1]
We focused on defining the detailed characteristic features of the corneal, iris, and angle parameters, as well as the Fourier indices based on the swept source optical coherence tomography (SS-OCT) of normal and Pseudoexfoliation syndrome (PEX) eye patients
Our study demonstrated that the AS-OCT-measured angle parameters in the PEX group were significantly smaller compared to those that were considered normal
Summary
Optical coherence tomography (OCT), is a non-contact precise tissue imaging technique that was developed in 1991 [1]. The CASIA2 (Corporation Tomey, Nagoya, Japan) is a commercially available device with a longitudinal resolution of 10 μm, a scanning speed of 50,000 A-scans/s, and a transverse resolution of 30 μm It is characterized by improved optical coherence, high reproducibility, and a scan frame size of 13 mm × 16 mm, which allows for data to be obtained from the surface of the cornea to the posterior surface of the lens in a single scan [6,7]. With respect to iris area, the parameters showed statistically significant differences between the PEX and control groups in all four quadrants of the eye. Conclusions: PEX syndrome is characterized by a significant impact on the anterior eye segment, including higher anterior and posterior keratometric values, lower anterior chamber depth, higher iris thickness, and narrower angle parameters. The characteristic anterior eye segment features of PEX syndrome can be detected using SS-OCT, which could potentially assist clinicians in properly managing the disease
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