Swelling kinetics of spray-dried chitosan acetate assessed by magnetic resonance imaging and their relation to drug release kinetics of chitosan matrix tablets

Abstract

Magnetic resonance imaging (MRI) was used to assess in situ swelling behaviors of spray-dried chitosan acetate (CSA) in 0.1N HCl, pH 6.8 and pH 5.0 Tris–HCl buffers. The in vitro drug releases from CSA matrix tablets containing the model drugs, diclofenac sodium and theophylline were investigated in all media using USP-4 apparatus. The effect of chitosan molecular weight, especially in pH 6.8 Tris–HCl, was also studied. In 0.1N HCl, the drug release from the matrix tablets was the lowest in relation to the highest swelling of CSA. The swelling kinetics in Tris–HCl buffers are Fickian diffusion according to their best fit to Higuchi’s model as well as the drug release kinetics in all the media. The high swelling rate (ks′) was found to delay the drug release rate (k′). The linear relationship between the swelling and fractions of drug release in Tris–HCl buffers was observed, indicating an important role of the swelling on controlling the drug release mechanism. Additionally, CSA of 200 and 800kDa chitosan did not swell in pH 6.8 Tris–HCl but disintegrated into fractions, and the drug release from the matrix tablets was the highest.