Abstract
Using poly(vinyl alcohol) as a drug model, the swelling behaviors of thermosensitive poly(N‐isopropylacrylamide) gel with various concentrations of PVA are investigated. The swelling ratio in PVA9000 is larger than that of PVA89000 at the same composition because the fully hydrolyzed PVA acts as a steric hindrance. A lattice‐based molecular thermodynamic model is used to obtain interaction parameters and then directly applied to describe the swelling behaviors of the gel. Using only one adjustable parameter, the PVA selectivity can be theoretically predicted and the ternary phase diagrams of PNIPA/water/PVA system can be generated. Lastly, the calculated results are compared with the swelling data for PNIPA/PVA copolymer gel, and are found to be in good agreement with the proposed model. image
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