Abstract
Mycobacterium tuberculosis infection is a common infection in developing countries, including India. It can induce several cutaneous reactions such as erythema nodosum, and erythema induratum; however, association of tuberculosis with Sweet's syndrome (also known as acute febrile neutrophilic dermatosis) is extremely rare. Here we present an interesting case of sputum-positive pulmonary tuberculosis with Sweet's syndrome. A 55-year-old female who was receiving a regimen of four antitubercular drugs (isoniazid, rifampicin, pyrazinamide, ethambutol- HRZE) for six weeks for sputum-positive pulmonary tuberculosis developed new onset high-grade fever for 15 days along with multiple reddish brown plaques and nodules involving the face as well as all four limbs of the body. Histopathology of the skin lesion was suggestive of Sweet's syndrome. The patient responded well to immunosuppressive steroid therapy.
Highlights
Sweet’s syndrome (SS) was named after Dr.Robert Douglas Sweet from Plymouth, England, who first described this condition in 1964
It was known as Gomm-Button disease in honour of the first two patients of Sweet’s syndrome diagnosed by Dr Sweet [1]
Case report A 55-year-old non-diabetic, non-hypertensive female patient was admitted in our institute with complaints of a high-grade continuous fever lasting 15 days along with the development of multiple reddishbrown elevated skin lesions mainly involving the face and all four limbs (Figures 1 and 2)
Summary
Sweet’s syndrome (SS) was named after Dr. Robert Douglas Sweet from Plymouth, England, who first described this condition in 1964. A case of Sweet’s syndrome with pulmonary tuberculosis and cervical cancer has been reported [17]. Case report A 55-year-old non-diabetic, non-hypertensive female patient was admitted in our institute with complaints of a high-grade continuous fever lasting 15 days along with the development of multiple reddishbrown elevated skin lesions mainly involving the face and all four limbs (Figures 1 and 2). The patient experienced respiratory distress and chest pain for the same duration She was receiving a regimen of four anti-tubercular drugs (isoniazid, rifampicin, pyrazinamide, ethambutol – HRZE) for the last six weeks for sputum-positive pulmonary tuberculosis. Histopathological features from skin lesions showed epidermal and subepidermal (reticular dermis) dense infiltration of acute inflammatory cells (PMNs) suggestive of Sweet’s syndrome (Figure 4)
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