Abstract
HIV Certain individuals infected with HIV, so-called neutralizers, generate broadly neutralizing antibodies more efficiently than non-neutralizers. Lofano et al. compared HIV-specific antibodies isolated from neutralizers and non-neutralizers. They found sialylation of the Fc domain to be higher in neutralizers. The authors generated sialylated and nonsialylated isoforms of an HIV gp120-specific antibody. Sialylation enhanced the deposition of antigen in B cell follicles in a complement-dependent manner. Besides stressing the importance of the Fc domain in regulating antibody functions, the study also highlights the role of the complement pathway in driving humoral immunity. Sci. Immunol. 3 , eaat7796 (2018).
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