Sweeteners as a Cause of Alteration in the Consumption of Food, Water, Variation in Percentage of Lymphocytes and Cytokines

Abstract

BACKGROUNDThe use of sweeteners influences the appetite, activation of immune responses and release of proinflammatory factors, causing increased glucose and weight, generating acute inflammation.OBJECTIVETo evaluate the effect of sweeteners as a cause of alterations in the consumption of food, water, variation in the percentages of lymphocytes and cytokines.MATERIAL AND METHODA total of 96 male mice CD1 [Crl: CD1 (ICR)] with eight week old, divided into three groups: CD1 (A), CD1 (B) and CD1 (C); each group with n = 32 subdivided into a control group: with a normal standard diet (rodent laboratory chow 5001 purine [3.02kcal/gr] and water ad libitum; one supplemented with sucrose (41.66 mg/mL), with stevia (4.16) mg/mL) and sucralose (4.16 mg/mL) respectively The weight, feed intake and water, percentage of B lymphocytes and cytokines (IL‐6, TNF‐a and INF‐g) were calculated initially, intermediate and final in each group.RESULTSMice with sucrose from the CD1 (A) group consume less food, more water and have high glucose levels. There is weight gain in the three CD1 (B) groups supplemented; mice with sucrose and sucralose consume more food; lymphocytes elevated in peyer's plates by sucrose and decreased in spleen and blood by stevia and sucralose. High levels of TNF‐a by sucrose and high initial levels of INF‐g by the three sweeteners; low levels at the end in CD1 (C).CONCLUSIONSSweeteners can influence as anorexigenic, however, they generate weight gain, elevation of glucose levels and acute inflammatory response.Support or Funding InformationAUTONOMOUS UNIVERSITY OF STATE OF MEXICO imageThis abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.