Abstract
Sweet Syndrome (SS) (acute febrile neutrophilic dermatosis) is an inflammatory disorder characterized by the appearance of painful, edematous, and erythematous papules, plaques, or nodules on the skin. It might also cause fever and internal organs’ involvement. There are three clinical settings in which SS has been described: classical or idiopathic, malignancy-associ¬ated and drug-induced. (1) SS is described in patients with acute promyelocytic leukemia (APL), and is a rare side effect of all-trans retinoic acid (ATRA), which causes differentiation of promyelocytes and used in therapy of APL. ATRA may also cause Differentiation Syndrome (DS), previously called retinoic acid syndrome, and there is overlap with SS. (2) There is a limited number of case reports describing SS in association with DS. We present here a case of SS associated with DS in a patient with APL treated with ATRA.
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