Abstract
Objective: This study is to understanding the transcription profile of nociception-related melanocortin receptor MC1R, obesity related neural melanocortin receptor Mc3r and MC4R. Methods: For MC1R, Mc3r and MC4R, relative luciferase activity RLA and the distribution of phosphorylation [P], glycosylation sites [G] on transcription factor for promoter model were plotted on the same chart. Results: Within the 3.2 kb upstream of the methionine ATG, for all three receptors, trend lines of RLA with that of [G] or ([P]-[G]), both tend to have negative reciprocal relationship. It brings up the question: for the neural receptors MC1R, Mc3r and MC4R, does the nutrition and obesity related glycosylation regulated the transcriptional activity in a negative reciprocal way? Conclusion: The negative reciprocal relation between trend line of [G] or ([P]-[G]) and that of RLA, give a specific digit evidence for the first time to the theory, which the structure related glycosylation and the signal sensing phosphorylation, exhibit either independently or Interactively on regulation of transcription activity.
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