Abstract
Samsakara (transformation) and Samyoga (combination) play major role in pharmaceutics. Samsakara is defined as Gunantaradhanam (transformation). Swedana is Agni Sannikarsha Samsakara. The changes in finished product because of Swedana Samsakara with two different media Jala and Gomutra can be perceived at pharmacognostical and phytochemical levels. Aims: To compare role of Swedana Samsakara with two different media Jala and Gomutra on basis of phyto-pharmacognostical, HPTLC and UV-VIS-NIR Reflectance (180-2500nm) study. Materials and Methods: In the present study, 3 samples were prepared viz. Haritaki Churna (Powder) (GH-1), Gomutra Swedita Haritaki(GH-3) and Jala Swedita Haritaki (GH-5), to compare role of Swedana Samsakara on basis of Pharmacognostical (powder microscopy), Pharmaceutical, HPTLC densitogram and UV-VIS-NIR reflectance (180-2500nm) study. Results: The samples prepared with different media showed difference in pharmacognostical, pharmaceutical, HPTLC and UV-VIS-NIR findings. Gomutra Swedita Haritaki(GH-3) had highest variation in all Phyto-Pharmacognostical, HPTLC and UV-VIS-NIR. Powder microscopy of GH-3 showed clumped epicarp cells, squashed mesocarp cells (not clear), parenchyma cells with brown content, cellular content was darker (brown) and crystalline material etc. Phytochemical parameters showed pH (7.0), loss on drying (9.303%w/w), ash value (15.84%w/w), water soluble extract (57.2%w/w), and alcohol soluble extract (43.5% w/w). HPTLC showed eight peaks at 256nm and 366nm. In UV-VIS-NIR, GH-3 has higher variation while other sample has higher leverage. GH-3 has apparent different profile from GH-1, GH-5. Conclusions: Swedana Samsakara effect was seen in both Jala and Gomutra but media (Samyoga) plays leading role to establish desired Gunas (qualities) and Karma (therapeutic action) in the final product.Â
Highlights
Samskara is defined as transformation (Gunantaradhanam) of the inherent attributes (Swabhavika Guna) of a substance which leads to the addition of new properties
The samples prepared with different media showed difference in pharmacognostical, pharmaceutical, HPTLC and UV-VIS-NIR findings
Pharmacognostical authentication of drug was done in ISSN: 0976-5921 Shivam Joshi et al, Phyto-pharmacognostical assay of Jala and Gomutra Swedita Haritaki pharmacognosy laboratory attached with institute while Gomutra(cow urine) was collected from Gaushala located in Dared village(Di
Summary
Samskara is defined as transformation (Gunantaradhanam) of the inherent attributes (Swabhavika Guna) of a substance which leads to the addition of new properties. Various methods of Samskaras(1) are mentioned in Ayurveda pharmaceutics such as Toyasannikarsa(Dilution), Agnisannikarsa or Swedana Samsakara(heat application), Saucha(cleaning), Manthana(churning), Desha(storing in a specific place), Kala(maturing), Vasana(container or preservation) and Bhavana (impregnation). Similar Gunas are found in Agneya Dravya (2), Swedana Dravya(3), Pitta and Katuka Rasa(4) which are Ushna, Tikshna, Sukshma, Laghu, Vishada, Sthira or Sara and Snighdh or Ruksha Guna. All above mentioned phenomena are having similar Paka Karma like Swedana Samsakara.
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