Abstract
Cystic fibrosis (CF) is the most common fatal genetic disease of the Caucasian population. Sweat testing is the principal diagnostic test for CF, and it is used for the evaluation of infants with positive CF newborn screening (NBS) and in patients with clinical findings suggesting CF. This article describes the classical sweat test method in detail and also provides an overwiew of recent advances.
Highlights
High concentrations of chloride (Cl−) detected in sweat from patients in the early 1940s resulted in the development of the sweat Cl− test (ST), and by 1959, the test was being used by Gibson and Cooke [1]
Detection of elevated values of sweat Cl− by the quantitative pilocarpine iontophoresis test (QPIT) performed via chloridometer is accepted as the gold standard in cystic fibrosis (CF) diagnosis
We review the QIPT and the newer alternatives being employed in the diagnosis of CF
Summary
Cystic fibrosis (CF) is the most common fatal genetic disease of the Caucasian population. Sweat testing is the principal diagnostic test for CF, and it is used for the evaluation of infants with positive CF newborn screening (NBS) and in patients with clinical findings suggesting CF. This article describes the classical sweat test method in detail and provides an overwiew of recent advances. Reviewed by: Aleksandar Sovtic, The Institute for Health Protection of Mother and Child Serbia, Serbia. Specialty section: This article was submitted to Pediatric Pulmonology, a section of the journal Frontiers in Pediatrics
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