Abstract
Abstract Swarnaprashana (SP) is a measure mentioned in the Ayurvedic literatures which can enhance immunity, intellect, and strength in children. It is prepared by rubbing gold on a stone in a mixture of honey and ghee and given to children for licking. In out-patient departments of some Ayurvedic hospitals, SP is administered to the children as part of immunization measures. SP contains gold nanoparticles. Gold nanoparticles have various activities in biological systems, including significant potential in various therapeutic applications and effect on the immune response. The gold nanoparticles strongly influence microglial activation; microglia are the resident immune cells of the brain. Microglia can reduce proinflammatory cytokine production, can stimulate phagocytosis caused by alveolar macrophages, and can inhibit neutrophil activation and mobilization. Gold nanoparticles are also effective as vaccine adjuvants and can potentiate activity of the vaccines. SP is applied to increase immunity in children. It is inferred that gold plays an important role in the effectiveness of SP. In this review article, we describe the application of SP for improving immunity in relation to the activity of gold nanoparticles.
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