Abstract
The predictors for fatal adenovirus (AdV) pneumonia among immunocompetent adults are unclear. Laboratory-confirmed, hospitalized AdV pneumonia adults were prospectively enrolled in Beijing Chao-Yang hospital from March to June 2013. Clinical data and serial whole blood and respiratory tract secretions from such patients were collected. Quantitative real-time polymerase chain reaction was performed to quantify the viral load. A total of 14 AdV pneumonia cases were consecutively enrolled, and four of them were fatal. Ten cases were caused by AdV-55, three by AdV-7 and one by AdV-3. There were no differences in age, gender or underlying diseases between the patients in the fatal cases and surviving cases. At admission (on day 5–7 after illness onset), the patients in fatal cases presented higher initial viral loads in respiratory tract secretions (8.578 ± 2.115 vs 6.263 ± 1.225 Log10 copies/ml, p = 0.023). All patients in fatal cases presented with viremia on day 12–14 (100% vs 66.7%, p = 0.017). A higher initial viral load in the respiratory tract and sustained viremia (more than 2 weeks) may be predictors for fatal clinical outcomes.
Highlights
Severe adenovirus (AdV) infections causing significant acute respiratory distress syndrome have raised concerns for immunocompetent adults [1]
From March 2013 to June 2013, a total of 14 admitted cases were confirmed with adenovirus as the only pathogen of pneumonia; four of the patients died in the ICU
We investigated the relationship between the virological factors and clinical outcomes in a cohort of 14 hospitalized adults with AdV pneumonia
Summary
Severe adenovirus (AdV) infections causing significant acute respiratory distress syndrome have raised concerns for immunocompetent adults [1]. Characteristic Age, (Mean ± SD) Male (%) Underlying diseases (%) Antibiotics before enrollment (%) AdV-55 (%) Days from onset of disease to initial viral PCR tests (Mean ± SD) Clinical features PSI Score (Mean ± SD) Tmax (°C) (Mean ± SD) Dyspnea (%) Hemoptysis (%) Yellow sputum (%) Diarrhea (%) Lab tests White blood cells (Mean±SD) (109/L) Leukocyte
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
