Abstract
Development and Characterization of Controlled Release Ketoprofen MicrospheresMarwa H. Abdallah, Omaima A. Sammour, Hanaa A. El-ghamry, Hanan M. El-nahas, Waleed Barakat
Highlights
In recent years oral controlled delivery systems have gained increased importance and interest since it is necessary to improve the systemic absorption of the drugs and patient compliance
The whole study was showed that the solid dispersion of Metoclopramide HCl sustained the release rate of drug for a prolong period of time at least 12 hrs and shows to increase the bioavailability and simultaneously decrease the dosing interval as well as dosing amount
Guar gum is a nonionic naturally occurring, hydrophilic polysaccharide obtained from the seeds of Cyamopsis tetragonolobus
Summary
In recent years oral controlled delivery systems have gained increased importance and interest since it is necessary to improve the systemic absorption of the drugs and patient compliance. Neha et al / Journal of Applied Pharmaceutical Science 5 (03); 2015: 055-065 It accelerates intestinal transit and gastric emptying by preventing relaxation of gastric body and increasing the phasic activity of antrum. Guar gum is a nonionic naturally occurring, hydrophilic polysaccharide obtained from the seeds of Cyamopsis tetragonolobus. It is used in solid dosage forms (binder and disintegrant), possess release retarding property and susceptibility to microbial degradation. It swells in cold water and forms viscous colloidal dispersions or sols. It is this gelling property that retards release of the drug from the dosage form. It was observed that guar gum alone acts as the release retarding polymer which follows a first-order release kinetic (Anupama et al, 2011)
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