Abstract
The preparation of magnetic nanoparticles coated with chitosan-prindopril erbumine was accomplished and confirmed by X-ray diffraction, TEM, magnetic measurements, thermal analysis and infrared spectroscopic studies. X-ray diffraction and TEM results demonstrated that the magnetic nanoparticles were pure iron oxide phase, having a spherical shape with a mean diameter of 6 nm, compared to 15 nm after coating with chitosan-prindopril erbumine (FCPE). Fourier transform infrared spectroscopy study shows that the coating of iron oxide nanoparticles takes place due to the presence of some bands that were emerging after the coating process, which belong to the prindopril erbumine (PE). The thermal stability of the PE in an FCPE nanocomposite was remarkably enhanced. The release study showed that around 89% of PE could be released within about 93 hours by a phosphate buffer solution at pH 7.4, which was found to be of sustained manner governed by first order kinetic. Compared to the control (untreated), cell viability study in 3T3 cells at 72 h post exposure to both the nanoparticles and the pure drug was found to be sustained above 80% using different doses.
Highlights
Drug nanoparticles are a drug delivery system with the ability to load, carry and release different types of drugs on target cells
Powder X-ray diffraction patterns of pristine naked Fe3O4 nanoparticles, Fe3O4 nanoparticles coated with chitosan (FC) and iron oxide nanoparticles coated with chitosan-perindopril erbumine (FCPE) are depicted in Figure 1A–C, respectively
(2θ = 30.2°, 35.7°, 43.3°, 53.9°, 63.2°) can be assigned as (220), (311), (400), (511) and (440), respectively. These peaks are consistent with the standard pattern (JCPDS No 19-629), which shows that the magnetite were pure iron oxide with a cubic inverse spinal structure. These peaks were observed in FCPE (Figure 1C); this indicates that the modification procedure did not change the crystal structure of iron oxide nanoparticles
Summary
Drug nanoparticles are a drug delivery system with the ability to load, carry and release different types of drugs on target cells. Polymers, including crosslinked dextran [3,4], poly(ethylene glycol) [5,6,7], poly(lactic acid) [8], poly(ethylene imine) (PEI) [9], polyvinyl alcohol [7,10] and chitosan [11] are widely used to amend the stability and biocompatibility of the superparamagnetic iron oxide nanoparticles [12,13,14]. Hydrophilic and partially acetylated glucosamine polymer with many useful properties, such as hydrophilicity, low immunogenicity, low toxicity, biocompatibility, and high biodegradability [14,15]. The cationic nature of chitosan permits for ionic cross linking with multivalent anions, and could be a suitable kind of polymer that can be used to modify the iron oxide nanoparticles. It is required that the magnetite nanoparticles possess high saturation magnetization for biomedical applications such as magnetic resonance imaging (MRI)
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