Abstract
Chitosan-poly(ɛ-caprolactone) was fabricated into drug-enclosed fibrous membranes by loading with ketoprofen and using a wet-spinning method. The optimized chitosan-poly(ɛ-caprolactone) fibrous membranes with poly(ɛ-caprolactone) proportions changing from about 20 to 40wt% showed notably enhanced tensile strength in wet state as compared to pure chitosan fibrous membranes. Some membranes loaded with an initial amount of around 8wt% ketoprofen were capable of maintaining sustained releases of ketoprofen for a period of time longer than 50h without significant initial burst release, and the corresponding release profiles could be effectively controlled by regulating the composition and diameters of the filaments. Kinetic analysis indicated that ketoprofen-release patterns from selected membranes were well fitted with Higuchi model and showed biphasic characteristics with different release-rate constants depending on the parameters of the membranes; and ketoprofen-releases were administrated by anomalous mechanisms involved both initial swelling and follow-up diffusion.
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