Abstract
The traditional method of injecting insulin requires multiple injections to stimulate the insulin secretion pattern physiologically, and injections have compliance and comfort issues. Microneedle s can reduce pain and are a patient-friendly technique. In this study, silk fibroin was utilized as a drug delivery system, which exhibited an excellent therapeutic effect by maintaining proper insulin activity. It makes a noninvasive alternative to traditional insulin administration by injection a reality and improves insulin use safety. The swelling capacity of the needle controls the release of insulin to stabilize the blood glucose concentration and achieve a long-term effect of lowering blood sugar. The relative effectiveness and bioavailability of the insulin-loaded microneedle patches were 69.4 ± 7.2% and 64.6 ± 9.5%, respectively, in hypoglycemic therapy in diabetic rats. Silk microneedle patches provide a new idea for solving the problem of cold chain transportation and bring new hope for the treatment of diabetes.
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