Abstract
We designed a novel sustained release preparation for chicken which resides in the gizzard and releases drug gradually following crushing due to the power of the gizzard. Considering the ease of administration, we selected hard granules consisting of a model drug, sulfamethoxazole (SMX), and polymers as the dosage form. When SMX was administered at a dose of 300 mg/kg as granules consisting of SMX (50%), EC (47.5%) and HPC (2.5%), the AUC value reached 72% of that in SMX powder. Moreover, the effective plasma concentration of SMX was maintained for approx. 4 days, which is 8-times longer than in the case of ordinary administration of SMX powder. The results suggest the possibility of development of sustained release dosage forms utilizing the frictional power of the gizzard.
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