Sustained Release Floating Matrix Tablets of Ciprofloxacin Using Combination of Different Polymers

Abstract

Drug delivery to the exact site of action become the key to the overall effectiveness of the drug, but when it comes to gastric ulcers it is a rate determining parameter and most crucial factor to play in the treatment of ulcers.More often, drug absorption is unsatisfactory and highly variable among and between individuals, despite excellent in vitro release patterns. The reasons for this are essentially physiological and usually affected by the GI transit of the form, especially its gastric residence time (GRT), which appears to be one of the causes of the overall transit time variability. Over the past three decades, the pursuit and exploration of devices designed to be retained in the upper part of the gastrointestinal (GI) tract has advanced consistently in terms of technology and diversity, encompassing a variety of systems and devices such as floating systems, raft systems, expanding systems, swelling systems, bioadhesive systems and low-density systems. Gastric retention will provide advantages such as the delivery of drugs with narrow absorption windows in the small intestinal region. Also, longer residence time in the stomach could be advantageous for local action in the upper part of the small intestine, for example treatment of peptic ulcer disease .The present research work aims to formulate and evaluate sustained release floating matrix tablets of Ciprofloxacin using combination of different polymers.