Abstract
Purpose: We have developed a protein-engineered thermo-responsive hydrogel, comprised of elastin (E) and cartilage oligomeric matrix protein coiled-coil (C), capable of providing sustained delivery of our chondroprotective engineered progranulin (PGRN)-derivative, Atsttrin (Tang et al., Science, 2011). Here, we characterize the impact of hydrogel delivered Atsttrin on chondrocyte viability and metabolism in vitro and describe the protective effects of injectable E5C hydrogel and Atsttrin-loaded E5C hydrogel in a rabbit anterior cruciate ligament transection (ACLT) induced model of post-traumatic osteoarthritis.
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