Abstract
The aim of this study was to test the sustained release of insulin-like growth factor-1 (IGF-1) and hepatocyte growth factor (HGF) using an injectable supramolecular hydrogel based on ureido-pyrimidinone (UPy) moieties in order to recruit and activate endogenous porcine cardiac stem/progenitor cells (epCSCs) towards the infarct borderzone leading to increased myocardial repair in a porcine model of chronic myocardial infarction (MI).
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