Abstract
This study intended to investigate the long-term antibacterial effect, mechanical performance, and surface topography of new anticaries dental composites. While most artificial aging studies of dental resins lasted for 30–90 days, this study prolonged the water-aging to one year to be more clinically relevant. The base resin was loaded with dimethylaminohexadecyl methacrylate (DMAHDM) at 3 or 5 wt.% and nano-sized amorphous calcium phosphate (NACP) at 20 wt.%. Composites were subjected to one-year water storage and wear. Following water aging, samples were evaluated for flexural strength, elastic modulus, and microbiological assays. Biofilm plate counting method, metabolic assay, colorimetric quantification of lactic acid, and Baclight bacterial viability assay were measured after one year. Topography changes (ΔRa, ΔRq, ΔRv, ΔRt) were examined after wear and observed by scanning electron microscopy. Biofilm assays and topography changes data were analyzed via one-way ANOVA and Tukey’s tests. Mechanical properties and normalized data were verified using a t-test. The flexural strength values for the formulations that contained 5% DMAHDM-20% NACP, 3% DMAHDM, and 5% DMAHDM were reduced significantly (p < 0.05) in relation to the baseline but the values were still above the ISO standards. No significant differences were observed between the groups concerning the topography changes, except for the ΔRt, where there was a significant increase in the 5% DMAHDM-20% NACP group. All the groups demonstrated robust biofilm-inhibition, with slightly reduced antibacterial properties following water aging. The aged samples reduced the total microorganisms, total streptococci, and mutans streptococci by 1.5 to 3-log, compared to the experimental control. The new formulations containing DMAHDM and NACP were able to sustain the antibacterial performance after one-year of aging. Mechanical properties and surface topography were slightly affected over time.
Highlights
The most used restorative materials for dental fillings are resin composites
This study aims to investigate the antibacterial effect, mechanical performance, and surface topography of new anticaries dental composites after one-year water storage and simulated wear
The bacterial log reduction demonstrated that the 3% dimethylaminohexadecyl methacrylate (DMAHDM)-20% nano-sized amorphous calcium phosphate (NACP) group was the only composite with a significantly reduced antibacterial action by around 1-log (Figure 3E)
Summary
The most used restorative materials for dental fillings are resin composites. They have excellent aesthetic characteristics, which mimic the natural teeth appearance [1]. Composites require less invasive cavity preparations compared to other restorative materials. Several investigations have been attempted to defeat this problem by imparting antibacterial additives into composite restorations [6]. Incorporating antibacterial agents to be released from the materials has shown limited long-term performance. Once the ion release occurs from a booster in the initial weeks to a few months, the amount of discharging decreases over time [7]. The approaches to overcome the limited release and promoted sustained ion release to convey an antibacterial effect are an ongoing investigation area
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