Abstract
Experiments were carried out on male Wistar rats to assess (1) the effect of chronically administered (for 20 days) scopolamine on their learning capacity and memory 10 days after its last administration and (2) the influence of the nootropic piracetam, given for 10 days after scopolamine and before learning a conditioned passive avoidance response, on cognitive functions of the brain altered as a result of the M-cholinergic receptors being blocked by scopolamine. Scopolamine-dosed rats showed poor reproduction of the conditioned passive avoidance response when tested for this response at 24 h and 30 days after learning it, whereas those treated with piracetam after scopolamine retained the response well both at 24 h and at 30 days. Piracetam also restored the scopolamine-impaired acute extinction of orienting/exploratory activity in the rats.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
