Abstract
Striatal acetylcholine release is decreased on activation of D 2 dopamine receptors. In the present study, it was investigated whether sustained activation of these receptors would reduce their capacity to mediate this effect. It was shown that activation for up to 2 h with high concentrations of either the endogenous ligand, dopamine, or the selective D 2 receptor agonist, LY 171555, did not induce desensitization of the D 2 receptor-mediated inhibited of electrically evoked [ 3H]acetylcholine release from rat striatal tissue slices. Dopamine D 2receptors; Acetylcholine release; Receptor desensitization; Receptor regulation; Striatum
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