Abstract
As life expectancy increases, the incidence of glaucoma is expected to rise worldwide. The review presents data on the comorbidity and polypharmacy of old and senile patients with glaucoma. Such patients also often have polypathia: on average, they have 6.3±0.6 concomitant somatic diseases. Approximately one in five glaucoma patients receives both a systemic and local beta-blocker ( ВВ ). Parallel use of local and systemic drugs in glaucoma patients is likely to cause drug interaction, increase side effects and contribute to an earlier onset of the tachyphylaxis. The selectivity of oral and local ВВ is one of the factors contributing to the prediction of their additive effect. The data on the expediency of prescribing brimonidine as the first-choice drug for glaucoma and hypertension patients who were previously prescribed systemic ВВ are presented.
Highlights
As life expectancy increases, the incidence of glaucoma is expected to rise worldwide
The selectivity of oral and local ВВ is one of the factors contributing to the prediction of their additive effect
В последнем десятилетии XX века и начале XXI века почти во всех регионах мира наблюдается тенденция демографического старения населения
Summary
The incidence of glaucoma is expected to rise worldwide. Согласно результатам исследования Ocular Hypertensive Treatment Study (OHTS, 2002), после 5 лет от начала лечения около 40 % пациентов с глаукомой нуждаются в 2, а еще 9 % больных — в 3 или более гипотензивных препаратах [4]. В ретроспективном исследовании историй болезни 100 пациентов с ПОУГ для определения наиболее распространенных системных препаратов, назначаемых в этой популяции, оказалось, что 84 пациента получали один или более лекарственный препарат (в среднем 3,5) при среднем количестве сопутствующих системных заболеваний 2,6.
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